Endonuclease G mediates a-synuclein cytotoxicity during Parkinson’s disease

Sabrina Büttner, Lukas Habernig, Filomena Broeskamp, Doris Ruli, F Nora Vögtle, Manolis Vlachos, Francesca Macchi, Victoria Küttner, Didac Carmona-Gutierrez, Tobias Eisenberg, Julia Ring, Maria Markaki, Asli Aras Taskin, Stefan Benke, Christoph Ruckenstuhl, Ralf Braun, Chris Van den Haute, Tine Bammens, Anke van der Perren, Kai-Uwe Fröhlich, Joris Winderickx, Guido Kroemer, Veerle Baekelandt, Nektarios Tavernarakis, Gabor G Kovacs, Jörn Dengjel, Chris Meisinger, Stephan J Sigrist* and Frank Madeo* Institute of Molecular Biosciences, University of Graz, Graz, Austria, Institute for Biology/Genetics, Freie Universität Berlin, Berlin, Germany, Institut für Biochemie und Molekularbiologie, ZBMZ, University of Freiburg, Freiburg, Germany, Institute of Molecular Biology and Biotechnology, Foundation for Research and TechnologyHellas, Crete, Greece, Neurobiology and Gene Therapy, KU Leuven, Leuven, Belgium, Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany, Faculty of Biology and Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany, Cell Biology, University of Bayreuth, Bayreuth, Germany, Functional Biology, KU Leuven, Leuven, Belgium, INSERM, U848, Villejuif, France, Metabolomics Platform, Institut Gustave Roussy, Villejuif, France, Centre de Recherche des Cordeliers, Paris, France, Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Institute of Neurology, Medical University of Vienna, Vienna, Austria and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany